Use of Lactobacillus paracasei isolated from whey for silver nanocomposite synthesis: Antiradical and antimicrobial properties against selected pathogens

摘要

The present research emphasizes the use of safe,inexpensive, and available whey using Lactobacillus paracaseias a source in silver nanocomposite synthesis asan alternative bioactive agent for dairy and biomedicalapplications. Through the multiinstrumental approachused in this study based on spectroscopic and microscopicmethods as well as spectrometric techniques, thecharacterization and evaluation of silver compositesand their antimicrobial and antiradical properties wereenabled. Synthesized silver nanocomposites have beenfound in form of nanocrystals, naturally coated by anorganic surface with high antimicrobial and antiradicalproperties. Furthermore, this work also presents aninnovative approach regarding the organic surface(naturally secreted by the bacteria isolated from whey)of the core of nanoparticles, which has already beenexplored and therefore is starting to supplement thescientific approach concerning biologically synthesizednanoparticles. This work also presents a general frameon the resistance subject by performing the trial interactionof commercially available antibiotics (kanamycinand ampicillin) with new bioactive compounds thatcan create novel knowledge on complementing theiraction. Moreover, synthesized silver nanocompositeshave shown great antioxidant and antimicrobial effectsagainst various foodborne pathogens from dairyproducts and drug resistance pathogens found in themedical area to rank on the top of mortality rate.