Effects of supplementing a Saccharomyces cerevisiae fermentation product during the periparturient period on the immune response of dairy cows fed fresh diets differing in starch content

摘要

The objective of this study was to evaluate the effectsof supplementing a Saccharomyces cerevisiae fermentationproduct (SCFP; NutriTek, Diamond V, CedarRapids, IA) during the periparturient period (d −28± 3 to 44 ± 3 relative to calving) on mRNA abundanceof genes in the rumen epithelium, inflammationindicators, oxidative status, and adaptive immunity ofdairy cows fed diets with different starch content aftercalving. From d 28 ± 3 (± standard deviation) beforethe expected calving date to calving, Holstein cows (n= 38) received a common basal controlled-energy closeupdiet (1.43 Mcal/kg, net energy for lactation; 13.8%starch) with (SCFP; n = 19) or without (CON; n =19) SCFP, and cows within each treatment (CON orSCFP) were fed either a low- (LS; 22.1% starch) orhigh-starch (HS; 28.3% starch) diet from d 1 to 23 ±3 after calving (fresh period). There were 4 treatmentgroups: LS + CON (n = 9), LS + SCFP (n = 10),HS + CON (n = 10), and HS + SCFP (n = 9). Fromd 24 ± 3 to 44 ± 3 after calving, all cows were fedthe HS diets (post-fresh period). Animal assignmentto treatments was balanced for parity, body conditionscore, and expected calving date. An interaction wasobserved between dietary starch content and SCFP onindices of oxidative stress; plasma concentrations oftotal antioxidant capacity tended to be reduced on d21 after calving for SCFP compared with CON cowswhen a LS fresh diet was fed, but did not differ for cowsfed HS fresh diets. Regardless of starch content, SCFPsupplementation increased plasma concentrations ofmalondialdehyde at d 21 after calving compared withCON. Supplementing with SCFP reduced serum concentrationsof haptoglobin on d 7 after calving, indicatingreduced inflammation, and feeding LS fresh dietsreduced mRNA abundance of IL receptor associatedkinase-1 in rumen tissue at d 21 after calving, suggestingreduced immune activation in rumen tissue. Otherthan the anti-inflammatory effects indicated by lowerserum haptoglobin concentration, no other effects oftreatment on adaptive immunity were detectable. Theseresults indicate that supplementing SCFP through thetransition period and feeding low-starch diets duringthe fresh period may reduce inflammation.