Unusual manifestations of type II cryoglobulinaemia associated with Waldenstrom's macroglobulinaemia

摘要

Cryoglobulinaemia in association with Waldenstrom's macroglobulinaemia is Relatively common, ranging from 8/100 to 18/100 of cases; however, <5/100 have symp- toms or complications. We describe a patient with a history of cutaneous, peri- toneal, and fallopian tube vasculitis re- lated to type II cryoglobulinaemia associated with Waldenstrom's macro- globulinaemia. Cytotoxic treatment was initiated (cyclophosphamide, vincristine, and prednisone) and had a good initial response. However, after the third course of chemotherapy, the patient presented with septic shock and died. Even though cryoglobulinaemia is a model of systemic vasculitis, peritoneal and fallopian tube vasculitis associated with type II cyoglob- ulinemia has not been described previ- ously.