Type 1 diabetes mellitus masking primary antibody deficiency

摘要

A patient with a history of recurrent cuta- neous and pulmonary infections, neph- rotic syndrome, and an established diagnosis of type 1 diabetes was found to have unsuspected and unrecognised pri- mary immunodeficiency. On review of the case, previous investigations pointed to the correct diagnosis over 10 years earlier. This combination of diagnoses has not Previously been reported. The patient is Now well on replacement intravenous Immunoglobulin therapy, urinary loss of IgG having been specifically excluded Before treatment. This case highlights how Antibody deficiency can easily be missed Despite an obvious infection history unless Results are interpreted carefully and in Context.