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Rapid diagnosis of intrapartum group B streptococcal carriage by fluorescent in situ hybridisation

机译:荧光原位杂交快速诊断产时B组链球菌转运。

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摘要

Group B streptococcus (GBS) still causes considerable neonatal morbidity and mortality. Early-onset infections (appearing within seven days of birth) account for about 80% of infections and are thought to arise from contact with the organism in the maternal genital tract during delivery. Data from the United States in the 1970s estimated an incidence rate of greater than 2 per 1000 live births, and case fatality rates approaching 50%. However, the use of intrapartum prophylaxis with antibiotics led to a 70% decline in GBS disease during the 1990s. In the UK, a recent study found an incidence of early-onset sepsis exceeding 0.72 per 1000 live births, with a mortality of 9.7%, rising to 15% in premature infants."
机译:B组链球菌(GBS)仍会引起相当大的新生儿发病率和死亡率。早发感染(在出生后七天内出现)约占感染的80%,并且被认为是由于分娩过程中与母体生殖道中的生物体接触而引起的。 1970年代美国的数据估计每千名活产婴儿的发病率大于2,病死率接近50%。但是,在1990年代,使用分娩期预防性使用抗生素导致GBS疾病下降了70%。在英国,最近的一项研究发现,每1000例活产中,败血症的发病率超过0.72,死亡率为9.7%,早产儿的这一比例上升到15%。”

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