Focal lymphoid aggregates (nodules) in bone marrow biopsies: differentiation between benign hyperplasia and malignant lymphoma-a practical guideline

摘要

Aims-To provide practical guidelines for the differentiation between benign and malignant focal lymphoid aggregates (lymphoid nodules) in routinely referred bone marrow trephine biopsies, using a synoptic approach including clinical data and histological workup. Methods-For easy identification of very Small lymphoid infiltrates the chloro- Acetate esterase stain was applied as a Screening procedure.