Study on Relative Bioavailability of Famotidine Sustained-re- lease Tablets in Healthy Volunteers

摘要

The relative bioavailability of famotidine sustained-release (SR) tablets was studied in 16 healthy male volunteers. Famotidine plasma concentration was determined by HPLC method, and the plasma concentration-time data were processed with the method provided by USP XXIII. For single dose administration the peak plasma concentration occurring at 8.13±0.34 h was 69.52±3.00 ng/ml and the relative bioavailability was 112.4±8.6 /100. For multiple dose administration the peak plasma concentration of SR tablet was 86.14±2.95 ng/ml and the degree of fluctuation (DF) was 140.6±13.5 /100 at steady state.