Total synthesis of (+/-)-abieta-8,11,13-trien-7 beta-ol

摘要

The first total synthesis of (+/-)-abieta-8,11,13-trien-7beta-ol (1) was accomplished, in which alpha-cyclocitral was used as the A ring synthon, and triphenylphosphonium chloride (9), which was obtained from m-bromobenzyl alcohol (4) via five steps, as the C ring synthon. The reduction of another natural organic compound (+/-)-abieta-8,11,13-trien-7-one (2) with LiAlH4 gave exclusively the title compound 1. [References: 15]