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首页> 外文期刊>Journal of Cancer Research and Clinical Oncology >Differential expression of retinoic acid receptors and p53 protein in normal, premalignant, and malignant esophageal tissues
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Differential expression of retinoic acid receptors and p53 protein in normal, premalignant, and malignant esophageal tissues

机译:正常,恶变前和恶性食管组织中视黄酸受体和p53蛋白的差异表达

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摘要

Purpose: Esophageal cancer remains a significant health problem worldwide. The very low 5-year survival rates and rapid increase in the incidence of adenocarcinoma indicate the urgent need for early identification of and new approaches to the prevention and treatment of this cancer. Methods: To find biomarkers for early identification of the disease, we analyzed nuclear retinoic retinoid receptor mRNAs, p53 protein, and the proliferation marker Ki 67 in surgical specimens of normal, mildly, and severely dysplastic and malignant esophageal tissues. Results: Nuclear retinoid receptors (RAR-α, RAR-γ, and RXR-α) were expressed in most (79%–100%) normal, dysplastic, and malignant esophageal mucosae, whereas expression of RAR-β was progressively lost from normal esophagus to carcinoma (84%–54%). In contrast, expression of p53 protein and Ki 67 were dramatically increased in severely dysplastic and cancerous tissues of the esophagus (from 5% to 62%). Conclusions: Loss of RAR-β expression and accumulation of p53 and Ki 67 proteins may serve as biomarkers for esophageal cancer.
机译:目的:食道癌仍然是世界范围内的重要健康问题。极低的5年生存率和腺癌发病率的迅速增加表明,迫切需要早期识别和预防这种癌症的新方法。方法:为了找到可早期识别疾病的生物标记物,我们分析了正常,轻度和严重增生和恶性食管组织手术标本中的核维甲酸类视黄醇受体mRNA,p53蛋白和增殖标记Ki 67。结果:大部分(79%–100%)正常,增生性和恶性食管粘膜表达核类维生素A受体(RAR-α,RAR-γ和RXR-α),而RAR-β的表达则从正常状态逐渐丧失食道癌(84%–54%)。相反,在食管的严重增生和癌变组织中,p53蛋白和Ki 67的表达显着增加(从5%到62%)。结论:RAR-β表达的丢失以及p53和Ki 67蛋白的积累可能是食管癌的生物标志物。

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    Central Laboratory for Tumor Biology Chinese Cancer Institute and Hospital Beijing 100021 China;

    Department of Pathology The University of Texas M.D. Anderson Cancer Center Houston Texas USA;

    Department of Clinical Cancer Prevention The University of Texas M.D. Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA Tel.: +1-713-7452940;

    Fax: +1-713-7920628 e-mail: xxu@mdanderson.org;

    Department of Clinical Cancer Prevention The University of Texas M.D. Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA Tel.: +1-713-7452940;

    Fax: +1-713-7920628 e-mail: xxu@mdanderson.org;

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  • 正文语种 eng
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  • 关键词

    Key words Nuclear retinoic acid receptors; p53; Ki 67; Esophageal cancer;

    机译:关键词核维甲酸受体;p53;Ki 67;食管癌;

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