The abnormal expression of retionic acid receptor-β, p53 and Ki67 protein in normal, premalignant and malignant esophageal tissues

摘要

Conclusion: Loss of RAR-βexpression and accumulation of p53 and Ki67 proteins may serve as biomarkers for early identification of esophageal cancer in the high-risk populations. Aim: Esophageal cancer remains a significant health Problem worldwide. It is important to investigate alterations In expression of retinoic acid receptor-β,p53 and Ki67 Proteins in esophageal carcinogenesis. Methods: To find biomarkers for early identification of Esophageal cancer, we analyzed and retinoic acid receptor-β, P53 protein and the proliferation marker Ki67 in surgical Specimens of normal, mildly, and severely dysplastic and Malignant esophageal tissues by in situ hybridization of RNA and immunohistochemistry.