Bendamustine induces G2 cell cycle arrest and apoptosis in myeloma cells: the role of ATM-Chk2-Cdc25A and ATM-p53-p21-pathways

Leander Gaul; Sonja Mandl-Weber; Philipp Baumann; Bertold Emmerich; Ralf Schmidmaier

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Bendamustine induces G2 cell cycle arrest and apoptosis in myeloma cells: the role of ATM-Chk2-Cdc25A and ATM-p53-p21-pathways

机译：苯达莫司汀诱导骨髓瘤细胞中的G2细胞周期停滞和凋亡：ATM-Chk2-Cdc25A和ATM-p53-p21-途径的作用

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Purpose Multiple myeloma is a fatal hematological disease caused by malignant transformation of plasma cells. Bendamustine has been proven to be a potent alternative to melphalan in phase 3 studies, yet its molecular mode of action is still poorly understood.

机译：目的多发性骨髓瘤是由浆细胞恶性转化引起的致命性血液病。在第3期研究中，苯达莫司汀已被证明是美法仑的有效替代品，但其分子作用方式仍知之甚少。

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《Journal of Cancer Research and Clinical Oncology》 |2008年第2期|p.245-253|共9页
作者
Leander Gaul; Sonja Mandl-Weber; Philipp Baumann; Bertold Emmerich; Ralf Schmidmaier;
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Multiple myeloma; Bendamustine; Cell cycle; Ataxia telangiectasia mutated protein; Checkpoint kinase 2;

机译：多发性骨髓瘤;苯达莫司汀;细胞周期;共济失调毛细血管扩张突变蛋白;检查点激酶2;

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1. Bendamustine induces G2 cell cycle arrest and apoptosis in myeloma cells: the role of ATM-Chk2-Cdc25A and ATM-p53-p21-pathways. [J] . Gaul L, Mandl-Weber S, Baumann P, Journal of Cancer Research and Clinical Oncology . 2008,第2期

机译：苯达莫司汀在骨髓瘤细胞中诱导G2细胞周期停滞和凋亡：ATM-Chk2-Cdc25A和ATM-p53-p21-途径的作用。
2. A novel phenylphthalimide derivative, pegylated TC11, improves pharmacokinetic properties and induces apoptosis of high-risk myeloma cells via G2/M cell-cycle arrest [J] . Shuji Aida, Masashi Hozumi, Daiju Ichikawa, Biochemical and Biophysical Research Communications . 2017,第1期

机译：一种新型苯乙二醇酰亚胺衍生物，聚乙二醇化TC11，通过G2 / M细胞循环骤停改善了药代动力学性质并诱导高危骨髓瘤细胞的凋亡
3. A natural peptide, dolastatin 15, induces G2/M cell cycle arrest and apoptosis of human multiple myeloma cells [J] . Masanori Sato, Morihiko Sagawa, Tomonori Nakazato, International journal of oncology . 2007,第6期

机译：天然肽dolastatin 15诱导人多发性骨髓瘤细胞的G2 / M细胞周期阻滞和凋亡
4. Curcuma zanthorrhiza Extracts Induce G2/M Cell Cycle Arrest and Apoptosis in 4T1 and MCF-7 Human Breast Cancer Cells [C] . Sari Haryanti, Galuh Ratnawati, Nuning Rahmawati International Symposium on Health Research;National Congress of The Indonesian Public Health Association . 2020

机译：Curcuma Zanthorrhiza提取物在4T1和MCF-7人乳腺癌细胞中诱导G2 / M细胞循环骤停和细胞凋亡
5. Cannabinol Inhibits Proliferation and Induces Cell Cycle Arrest and Apoptosis in Glioblastoma, Hepatocellular Carcinoma and Breast Cancer Cells [D] . Zhong, Nuanying. 2020

机译：大麻素抑制胶质母细胞瘤，肝细胞癌和乳腺癌细胞中的增殖和诱导细胞周期停滞和凋亡
6. Pfaffosidic Fraction from Hebanthe paniculata Induces Cell Cycle Arrest and Caspase-3-Induced Apoptosis in HepG2 Cells [O] . Tereza Cristina da Silva, Bruno Cogliati, Andréia Oliveira Latorre, 2015

机译：来自Hepanthe paniculata的翼状Fra肉成分诱导HepG2细胞的细胞周期阻滞和Caspase-3诱导的细胞凋亡。
7. Levels of p53 in Epstein–Barr Virus-Infected Cells Determine Cell Fate: Apoptosis, Cell Cycle Arrest at the G1/S Boundary without Apoptosis, Cell Cycle Arrest at the G2/M Boundary without Apoptosis, or Unrestricted Proliferation [O] . Chen Weiping, Huang Shuang, Cooper Neil R. 1998

机译：爱泼斯坦-巴尔病毒感染的细胞中p53的水平决定了细胞的命运：细胞凋亡，在没有细胞凋亡的G1 / S边界处的细胞周期停滞，在没有细胞凋亡的G2 / M边界处的细胞周期停滞或增殖不受限制

Bendamustine induces G2 cell cycle arrest and apoptosis in myeloma cells: the role of ATM-Chk2-Cdc25A and ATM-p53-p21-pathways

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