Remote Effects in Macrolide Formation through Ring-Forming Olefin Metathesis: An Application to the Synthesis of Fully Active Epothilone Congeners

摘要

In summary, a route to (E)- and (Z)-desoxyepothilones using ROM technology has been accomplished. Through this and related methodology to be described soon, highly biologically active congeners have been obtained, and a total synthesis driven mapping of the SAR of epothilones is well underway.