Cyclopropylazetoindolines as Precursors to C(3)-Quaternary-Substituted Indolines

摘要

In light of their presence in a wide variety of structurally complexnand biologically active substrates, including those shown in Figuren1,n1 3nit is not surprising that C(3)-quaternary-substituted pyrro-nloindolines have received a significant amount of attention fromnthe synthetic and medicinal chemistry communities.n4,5nWhile annumber of very elegant approaches to these structures have beenndescribed,n6nnew and especially more general routes are still needed.nOutlined here are our efforts to help to address this problem throughnthe use of a new class of fused heterocycles, cyclopropylazetoin-ndolines, as useful electrophiles in the synthesis of C(3)-quaternary-nsubstituted pyrroloindolines.