Asymmetric synthesis of N-diphenylphosphinoylamines by solvent-free enantioselective addition of dialkylzincs to N-diphenylphosphinoylimines

摘要

Solvent-free enantioselective addition of dialkylzincs tonN-diphenylphosphinoylimines in the presence of chiral 2-nmorpholino-1-phenylpropan-1-ol affords N-diphenylphosphinoylaminesnwith up to 97% ee. The reaction in thensolvent-free system is faster than in organic solvents.