A phase I/II trial of celecoxib with chemotherapy and radiotherapy in the treatment of patients with locally advanced oesophageal cancer

S. J. Dawson; M. Michael; J. Biagi; K. F. Foo; M. Jefford; S. Y. Ngan; T. Leong; A. Hui; A. D. Milner; R. J. S. Thomas; J. R. Zalcberg

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A phase I/II trial of celecoxib with chemotherapy and radiotherapy in the treatment of patients with locally advanced oesophageal cancer

机译：塞来昔布联合化疗和放疗治疗局部晚期食管癌患者的I / II期试验

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Background: The study's aim was to determine the maximum tolerated dose (MTD) of celecoxib combined with chemoradiotherapy (CRT) for locally advanced oesophageal cancer (OC).

机译：背景：这项研究的目的是确定塞来昔布联合放化疗（CRT）对局部晚期食管癌（OC）的最大耐受剂量（MTD）。

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来源
《Investigational New Drugs》 |2007年第2期|123-129|共7页
作者
S. J. Dawson; M. Michael; J. Biagi; K. F. Foo; M. Jefford; S. Y. Ngan; T. Leong; A. Hui; A. D. Milner; R. J. S. Thomas; J. R. Zalcberg;
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作者单位

Department of Haematology and Medical Oncology Peter MacCallum Cancer Centre Locked Bag 1 A’Beckett St Victoria 8006 Australia;

Department of Haematology and Medical Oncology Peter MacCallum Cancer Centre Locked Bag 1 A’Beckett St Victoria 8006 Australia;

Department of Haematology and Medical Oncology Peter MacCallum Cancer Centre Locked Bag 1 A’Beckett St Victoria 8006 Australia;

Department of Haematology and Medical Oncology Peter MacCallum Cancer Centre Locked Bag 1 A’Beckett St Victoria 8006 Australia;

Department of Haematology and Medical Oncology Peter MacCallum Cancer Centre Locked Bag 1 A’Beckett St Victoria 8006 Australia;

Department of Radiation Oncology Peter MacCallum Cancer Centre Locked Bag 1 A’Beckett St Victoria 8006 Australia;

Department of Radiation Oncology Peter MacCallum Cancer Centre Locked Bag 1 A’Beckett St Victoria 8006 Australia;

Department of Radiation Oncology Peter MacCallum Cancer Centre Locked Bag 1 A’Beckett St Victoria 8006 Australia;

Centre for Biostatistics and Clinical Trials Peter MacCallum Cancer Centre Locked Bag 1 A’Beckett St Victoria 8006 Australia;

Division of Surgical Oncology Peter MacCallum Cancer Centre Locked Bag 1 A’Beckett St Victoria 8006 Australia;

Department of Haematology and Medical Oncology Peter MacCallum Cancer Centre Locked Bag 1 A’Beckett St Victoria 8006 Australia;

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原文格式 PDF
正文语种 eng
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关键词
Celecoxib; Chemotherapy; Oesophageal cancer; Radiotherapy;

机译：塞来昔布;化学疗法;食道癌;放射疗法;

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专利

1. A phase I/II trial of celecoxib with chemotherapy and radiotherapy in the treatment of patients with locally advanced oesophageal cancer. [J] . Dawson SJ, Michael M, Biagi J, Investigational new drugs. . 2007,第2期

机译：塞来昔布联合化疗和放疗在局部晚期食道癌患者中进行的I / II期试验。
2. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and G [J] . Bartelink H, Roelofsen F, Eschwege F, Journal of Clinical Oncology . 1997,第5期

机译：在局部晚期肛门癌的治疗中，伴随放疗和化疗优于单纯放疗：欧洲癌症放疗和治疗研究与治疗组织III期随机试验的结果
3. Induction chemotherapy followed by concurrent chemotherapy and definitive high-dose radiotherapy for patients with locally advanced non-small-cell lung cancer (stages IIIa/IIIb): a pilot phase I/II trial. [J] . Pottgen C, Eberhardt W, Bildat S, Annals of oncology: official journal of the European Society for Medical Oncology . 2002,第3期

机译：对于局部晚期非小细胞肺癌患者（IIIa / IIIb期），诱导化疗，同步化疗和确定性大剂量放疗：I / II期试验性试验。
4. Neoadjuvant treatment in rectal cancer: do we always need radiotherapy-or can we risk assess locally advanced rectal cancer better? [C] . Rob Glynne-Jones St. Gallen EORTC Gastrointestinal Cancer Conference . 2012

机译：Neoadjuvant在直肠癌中治疗：我们总是需要放射治疗 - 或者我们是否可以更好地评估当地先进的直肠癌？
5. Treatment Patterns and Cost-Effectiveness of Chemotherapy Treatments among Advanced Gastric Cancer Patients [D] . Haag, Austin Jade. 2017

机译：晚期胃癌患者化学疗法的治疗模式和成本效益
6. Dose-escalated radiotherapy with PET/CT based treatment planning in combination with induction and concurrent chemotherapy in locally advanced (uT3/T4) squamous cell cancer of the esophagus: mature results of a phase I/II trial [O] . C. Pöttgen, E. Gkika, M. Stahl, 2021

机译：剂量升级的放疗与PET / CT的治疗计划与局部晚期（UT3 / T4）鳞状细胞癌的诱导和同时化疗联合食管：I / II期试验的成熟结果
7. Individualized Adaptive Radiotherapy versus Standard Radiotherapy with Chemotherapy for Patients with Locally Advanced Non-Small Cell Lung Cancer: A Multicenter Randomized Phase III Clinical Trial CRTOG1601 [O] . S. Yuan, Q. Yu, S. Wang, 2020

机译：个性化适应性放射治疗与局部晚期非小细胞肺癌患者的化疗与标准放射治疗：多中心随机期III临床试验CRTOG1601

A phase I/II trial of celecoxib with chemotherapy and radiotherapy in the treatment of patients with locally advanced oesophageal cancer

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