Whole grains and resistant starch rich, reduced-calorie biscuit diet as a hypoglycaemic, hypolipidaemic and insulin stimulator in streptozotocin-induced diabetic rats

摘要

A fibre-enriched, reduced-calorie biscuit [formulated biscuit (FB)] was evaluated for its antidiabetic and antilipidaemic potential in streptozotocin-induced diabetes in Wistar rats against control biscuit (CB) having high calorie and low fibre content. Animals were allocated into five groups: a control group fed with synthetic diet, two diabetes-induced groups (CBD and FBD) and two nondiabetic groups (CBND and FBND). CBD and CBND were fed with synthetic diet + CB while FBD and FBND were fed with synthetic diet + FB. After 6 weeks of feeding, the change in weight of nondiabetic group fed with FB (+16.20%) was nonsignificantly lower compared to control (+33.01%) and CB-fed (+34.55%) group. Nonsignificant loss in body weight was observed among diabetic group fed with FB (-11.76%) or CB (-36.88%). Feeding of FB led to a significant decrease in fasting and postprandial blood glucose levels, total cholesterol, triglycerides, LDL-C, VLDL-C and atherosclerotic index and increase the HDL-C. His-tological examination showed that feeding of FB was able to partially recover the destroyed β-cell in STZ-induced diabetic rats.