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首页> 外文期刊>International Journal of Epidemiology >Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals
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Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals

机译：15q25基因变异，吸烟量与17,000名个体中与烟草有关的癌症之间的关联

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摘要

Background Genetic variants in 15q25 have been identified as potential risk markers for lung cancer (LC), but controversy exists as to whether this is a direct association, or whether the 15q variant is simply a proxy for increased exposure to tobacco carcinogens.
机译：背景技术15q25中的遗传变异已被确定为肺癌（LC）的潜在危险标志物，但是关于这是否是直接关联还是15q变异是否仅仅是增加烟草致癌物暴露的替代品存在争议。

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  • 来源
    《International Journal of Epidemiology 》 |2010年第2期| p.563-577| 共15页
  • 作者

    Esther H Lips; Valerie Gaborieau; James D McKay; Amelie Chabrier; Rayjean J Hung; Paolo Boffetta; Mia Hashibe; David Zaridze; Neonilia Szeszenia-Dabrowska; Jolanta Lissowska; Peter Rudnai; Eleonora Fabianova; Dana Mates; Vladimir Bencko; Lenka Foretova; Vladimir Janout; John K Field; Triantafillos Liloglou; George Xinarianos; John McLaughlin; Geoffrey Liu; Frank Skorpen; Maiken Bratt Elvestad; Kristian Hveem; Lars Vatten; EPIC Study; Simone Benhamou; Pagona Lagiou; Ivana Holcátová; Franco Merletti; Kristina Kjaerheim; Antonio Agudo; Xavier Castellsagué; Tatiana V Macfarlane; Luigi Barzan; Cristina Canova; Ray Lowry; David I Conway; Ariana Znaor; Claire Healy; Maria Paula Curado; Sergio Koifman; Jose Eluf-Neto; Elena Matos; Ana Menezes; Leticia Fernandez; Andres Metspalu; Simon Heath; Mark Lathrop;

  • 作者单位

    International Agency for Research on Cancer (IARC), Lyon, France.;

    International Agency for Research on Cancer (IARC), Lyon, France.;

    International Agency for Research on Cancer (IARC), Lyon, France.;

    International Agency for Research on Cancer (IARC), Lyon, France.;

    International Agency for Research on Cancer (IARC), Lyon, France.|Samuel Lunenfeld Research Institute of the Mount Sinai Hospital, Toronto, Canada.;

    International Agency for Research on Cancer (IARC), Lyon, France.;

    International Agency for Research on Cancer (IARC), Lyon, France.;

    Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russia.;

    Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland.;

    Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland.;

    Johan National Institute of Public Health, Budapest, Hungary.;

    Regional Authority of Public Health in Banska Bystrica, Banska Bystrica, Slovakia.;

    Institute of Public Health, Bucharest, Romania.;

    Institute of Hygiene and Epidemiology, First Faculty of Medicine and General University Hospital, Charles University in Prague, Czech Republic.;

    Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.;

    Palacky University, Olomouc, Czech Republic.;

    Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre, Liverpool, UK.;

    Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre, Liverpool, UK.;

    Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre, Liverpool, UK.;

    Samuel Lunenfeld Research Institute of the Mount Sinai Hospital, Toronto, Canada.|Cancer Care Ontario, Toronto, Canada.;

    Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Canada.;

    Norwegian University of Science and Technology, Trondheim, Norway.;

    Norwegian University of Science and Technology, Trondheim, Norway.;

    Norwegian University of Science and Technology, Trondheim, Norway.;

    Norwegian University of Science and Technology, Trondheim, Norway.;

    A full list of authors appears in the Appendix list.;

    INSERM U794, Paris, France.|Institut Gustave Roussy, Villejuif, France.;

    University of Athens School of Medicine, Athens, Greece.;

    Institute of Hygiene and Epidemiology, First Faculty of Medicine and General University Hospital, Charles University in Prague, Czech Republic.;

    Cancer Epidemiology Unit and CeRMS, University of Turin, Turin, Italy.;

    Cancer Registry of Norway, Oslo, Norway.;

    Institut Català d'Oncologia (ICO)-IDIBELL, L'Hopitalet de Llobregat, Spain.;

    Institut Català d'Oncologia (ICO)-IDIBELL, L'Hopitalet de Llobregat, Spain.|CIBERESP, Barcelona, Spain.;

    University of Aberdeen School of Medicine, Aberdeen, UK.;

    General Hospital, Pordenone, Italy.;

    Department of Environmental Medicine and Public Health, University of Padua, Padua, Italy.;

    University of Newcastle Dental School, Newcastle, UK.;

    University of Glasgow Medical Faculty Dental School, Glasgow, UK.;

    Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia.;

    Trinity College School of Dental Science, Dublin, Ireland.;

    International Agency for Research on Cancer (IARC), Lyon, France.|Hospital Araujo Jorge, Goiania, and Populational Cancer Register of Goiania, Goiania, Brazil.;

    Escola Nacional de Saude Publica, Rio de Janeiro, Brazil.;

    Universidade de Sao Paulo, Sao Paulo, Brazil.;

    Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina.;

    Universidade Federal de Pelotas, Pelotas, Brazil.;

    Institute of Oncology and Radiobiology, Havana, Cuba.;

    Estonian Genome Project, Institute of Molecular and Cell Biology, University of Tartu/Estonian Biocentre, Tartu, Estonia.;

    Centre National de Genotypage, Institut Genomique, Comissariat à l'énergie Atomique, Evry, France.;

    Centre National de Genotypage, Institut Genomique, Comissariat à l'énergie Atomique, Evry, France.|Fondation Jean Dausset-CEPH, Paris, France.;

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