Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene

Toshirou Nishida; Tsuyoshi Takahashi; Akiko Nishitani; Toshihiko Doi; Kuniaki Shirao; Yoshito Komatsu; Kiyokazu Nakajima; Seiichi Hirota

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Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene

机译：耐舒尼替尼的胃肠道间质瘤在KIT基因的激活环中具有顺式突变

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Although sunitinib malate has shown significant clinical effect on imatinib-resistant gastrointestinal stromal tumors, with acceptable tolerability and improved prognosis for the patients, the mechanism of resistance to the drug is still under investigation.

机译：尽管苹果酸舒尼替尼对伊马替尼耐药的胃肠道间质瘤已显示出显着的临床效果，具有可接受的耐受性并改善了患者的预后，但对这种药物的耐药机制仍在研究中。

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来源
《International Journal of Clinical Oncology》 |2009年第2期|143-149|共7页
作者
Toshirou Nishida; Tsuyoshi Takahashi; Akiko Nishitani; Toshihiko Doi; Kuniaki Shirao; Yoshito Komatsu; Kiyokazu Nakajima; Seiichi Hirota;
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作者单位

Department of Surgery Osaka University Graduate School of Medicine 2-2 Yamadaoka Suita Osaka 565-0871 Japan;

Department of Surgery Osaka University Graduate School of Medicine 2-2 Yamadaoka Suita Osaka 565-0871 Japan;

Department of Surgery Osaka University Graduate School of Medicine 2-2 Yamadaoka Suita Osaka 565-0871 Japan;

Division of Gastrointestinal Oncology/Digestive Endoscopy National Cancer Center Hospital East Chiba Japan;

Department of Medical Oncology National Cancer Center Hospital Tokyo Japan;

Department of Gastroenterology Hokkaido University Graduate School of Medicine Hokkaido Japan;

Department of Surgery Osaka University Graduate School of Medicine 2-2 Yamadaoka Suita Osaka 565-0871 Japan;

Department of Surgical Pathology Hyogo Medical College Kobe Japan;

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原文格式 PDF
正文语种 eng
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关键词
Acquired resistance; KIT; Imatinib; Sunitinib; Mutation;

机译：获得性耐药;KIT;伊马替尼;舒尼替尼;突变;
入库时间 2022-08-18 00:10:38

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专利

1. Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene. [J] . Nishida T, Takahashi T, Nishitani International journal of clinical oncology . 2009,第2期

机译：耐舒尼替尼的胃肠道间质瘤在KIT基因的激活环中具有顺式突变。
2. Rapid relapse after resection of a sunitinib-resistant gastrointestinal stromal tumor harboring a secondary mutation in exon 13 of the c-KIT gene [J] . KikuchiH., MiyazakiS., SetoguchiT., Anticancer Research: International Journal of Cancer Research and Treatment . 2012,第9期

机译：切除耐舒尼替尼的胃肠道间质瘤后迅速复发，该肿瘤在c-KIT基因第13外显子中具有继发突变
3. Inactivity of imatinib in gastrointestinal stromal tumors (GISTs) harboring a KIT activation-loop domain mutation (exon 17 mutation pN822K) [J] . Gianluca Spitaleri, Roberto Biffi, Massimo Barberis, OncoTargets and therapy . 2015,第2期

机译：伊马替尼在具有KIT激活环结构域突变（外显子17突变pN822K）的胃肠道间质瘤（GIST）中不活动
4. Malignancy Prediction of Gastrointestinal Stromal Tumors by Evaluating Tumor Vessel Density from Enhanced Spiral CT Scan [C] . Jintao Li, Cihu Yu, Chang Li, International Conference on Communications, Information Management and Network Security . 2019

机译：通过增强螺旋CT扫描评价肿瘤血管密度的恶性肿瘤性质肿瘤
5. Roles of insulin-like growth factor binding protein-3 in gastrointestinal stromal tumors. [D] . Dupart, Jheri J. 2009

机译：胰岛素样生长因子结合蛋白3在胃肠道间质瘤中的作用。
6. Inactivity of imatinib in gastrointestinal stromal tumors (GISTs) harboring a KIT activation-loop domain mutation (exon 17 mutation pN822K) [O] . Gianluca Spitaleri, Roberto Biffi, Massimo Barberis, 2015

机译：伊马替尼在具有KIT激活环结构域突变（外显子17突变pN822K）的胃肠道间质瘤（GIST）中不活跃
7. Activating mutations in c-KIT and PDGFRα are exclusively found in gastrointestinal stromal tumors and not in other tumors overexpressing these imatinib mesylate target genes [O] . Kk Burger, Michael A. den Bakker, Johan M. Kros, 2005

机译：C-kit和PDGFRα中的激活突变仅在胃肠道基质肿瘤中发现，而不是在其他肿瘤中过表达这些伊马替尼甲磺酸酯靶基因的肿瘤

Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene

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