Genes In Overweight People Respond Differently To Diet Than Genes In Lean People

摘要

Recent research by TNO, the Dutch institute for applied scientific research, shows that anges in diet have a marked effect on gene expression in fat tissue. In the study, scientists found that fat cells in lean and overweight men react distinctly different to changes in their diet. This result confirms the growing insight that fat tissue responds actively to dietary changes. It also increases our understanding of how fat tissue acts in diseases related to obesity, like diabetes type 2. The findings appeared in the December issue of Genes and Nutrition.rnIn this pioneering study, TNO scientists analyzed the activity of genes in fat tissue biopsies taken from human volunteers. Senior scientist human physiology, Henk Hendriks of TNO explains the novel nature of the study's findings: "For the first time, we show that a short-term diet change has an effect on the activity of genes that play a role in inflammatory processes in fat tissue of people who are overweight.The technique is an example of nutrigenomics research, and it allows us to investigate the effect of complex mixtures of functional food ingredients on fat tissue. The first findings show that genes in fat tissue are sensitivernto diet changes. The result also strengthens our hypothesis that fat tissue is actively involved in the development of obesity-related disease."