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Exploring the Solution Space of Sorting by Reversals, with Experiments and an Application to Evolution

机译:通过实验探索逆转排序的解决方案空间及其在进化中的应用

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In comparative genomics, algorithms that sort permutations by reversals are often used to propose evolutionary scenarios of rearrangements between species. One of the main problems of such methods is that they give one solution while the number of optimal solutions is huge, with no criteria to discriminate among them. Bergeron et al. started to give some structure to the set of optimal solutions, in order to be able to deliver more presentable results than only one solution or a complete list of all solutions. However, no algorithm exists so far to compute this structure except through the enumeration of all solutions, which takes too much time even for small permutations. Bergeron et al. state as an open problem the design of such an algorithm. We propose in this paper an answer to this problem, that is, an algorithm which gives all the classes of solutions and counts the number of solutions in each class, with a better theoretical and practical complexity than the complete enumeration method. We give an example of how to reduce the number of classes obtained, using further constraints. Finally, we apply our algorithm to analyse the possible scenarios of rearrangement between mammalian sex chromosomes.
机译:在比较基因组学中,按逆序排列排列的算法通常用于提出物种间重排的进化方案。这种方法的主要问题之一是,它们只能给出一个解,而最优解的数量是巨大的,没有判别标准。 Bergeron等。开始为一组最佳解决方案提供某种结构,以便能够提供比仅一个解决方案或所有解决方案的完整列表更具表现力的结果。但是,到目前为止,除了通过所有解决方案的枚举之外,还没有算法可以计算出这种结构,即使对于很小的排列,也要花费大量的时间。 Bergeron等。状态作为一个开放的问题,这种算法的设计。我们在本文中提出了对此问题的答案,即一种算法,该算法提供所有类别的解决方案并计算每个类别中的解决方案数量,其理论和实践复杂度均比完整的枚举方法更好。我们给出一个示例,说明如何使用进一步的约束来减少获得的类的数量。最后,我们应用我们的算法来分析哺乳动物性染色体之间重排的可能情况。

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