DNA methylation patterns of spermatozoa and two generations of offspring obtained after murine spermatogonial stem cell transplantation

E. Goossens15 M. De Rycke12 P. Haentjens3 and H. Tournaye14

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DNA methylation patterns of spermatozoa and two generations of offspring obtained after murine spermatogonial stem cell transplantation

机译：小鼠精原干细胞移植后获得的精子和两个后代的DNA甲基化模式

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BACKGROUND Apart from its use in research, spermatogonial stem cell transplantation (SSCT) may have important clinical applications. This controlled study aimed at evaluating the safety of SSCT by analyzing the DNA methylation pattern of Igf2, Peg1 and α-Actin both in spermatozoa and live born offspring obtained after SSCT in mice.

机译：背景技术除了用于研究之外，精原干细胞移植（SSCT）可能具有重要的临床应用。这项对照研究旨在通过分析小鼠精子和活体后代中Igf2，Peg1和α-肌动蛋白的DNA甲基化模式来评估SSCT的安全性。

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《Human Reproduction》 |2009年第9期|p.2255-2263|共9页
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E. Goossens15 M. De Rycke12 P. Haentjens3 and H. Tournaye14;
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1Research Laboratory for Embryology and Genetics, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium 2Centre for Medical Genetics, UZ Brussel, Vrije Universiteit Brussel (VUB), Laarbeeklaan 101, 1090 Brussels, Belgium 3Centre for Outcomes Research and Laboratory for Experimental Surgery, UZ Brussel, Vrije Universiteit Brussel (VUB), Laarbeeklaan 101, 1090 Brussels, Belgium 4Centre for Reproductive Medecine, UZ Brussel, Vrije Universiteit Brussel (VUB), Laarbeeklaan 101, 1090 Brussels, Belgium;

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1. DNA methylation patterns of spermatozoa and two generations of offspring obtained after murine spermatogonial stem cell transplantation. [J] . Goossens E, De Rycke M, Haentjens P Human Reproduction . 2009,第9期

机译：小鼠精原干细胞移植后获得的精子和两个后代的DNA甲基化模式。
2. Array comparative genomic hybridization analysis does not show genetic alterations in spermatozoa and offspring generated after spermatogonial stem cell transplantation in the mouse. [J] . Goossens E, de Vos P, Tournaye H Human Reproduction . 2010,第7期

机译：阵列比较基因组杂交分析未显示小鼠精原干细胞移植后产生的精子和后代的遗传改变。
3. Array comparative genomic hybridization analysis does not show genetic alterations in spermatozoa and offspring generated after spermatogonial stem cell transplantation in the mouse† [J] . E. Goossens, P. de Vos Human Reproduction . 2010,第7期

机译：阵列比较基因组杂交分析未显示小鼠精原干细胞移植后精子和后代产生的遗传改变†
4. THERMOSTABILITY STUDIES OF DESICCATED MURINE SPERMATOZOA NUCLEAR DNA TO PREDICT THE BENEFICIAL EFFECT OF TREHALOSE IN LONG TERM STORAGE [C] . Sankha Bhowmick, Bharat D. Nath, John D. Biggers, 2002 ASME International Mechanical Engineering Congress and Exposition , Nov 17-22, 2002, New Orleans, Louisiana . 2002

机译：脱水鼠精子核DNA预测海藻糖长期保存的有益效果的热稳定性研究
5. Effect of Maternal Dietary B-Vitamin Intake on Offspring DNA Methylation Patterns, Gene Expression, Cytokinetics, and Intestinal Tumorigenesis in the Apc+/1638N Mouse Model. [D] . Ciappio, Eric D. 2011

机译：母体饮食中维生素B摄入对Apc + / 1638N小鼠模型中后代DNA甲基化模式，基因表达，细胞动力学和肠道肿瘤发生的影响。
6. Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring [O] . Chao-Hui Li, Lan-Zhen Yan, Wen-Zan Ban, 2017

机译：树sh精原干细胞在培养中的长期繁殖及成功转基因后代的产生
7. Preservation of chromosomal integrity in murine spermatozoa derived from gonocytes and spermatogonial stem cells surviving prenatal and postnatal exposure to γ-rays in mice [O] . Hiroyuki Watanabe, Atsushi Kohda, Jun-ichiro Komura, 2017

机译：从腺细胞和精牙科干细胞衍生的狼蛛精子中的染色体完整性保存产前和产前暴露于小鼠γ射线的γ射线

DNA methylation patterns of spermatozoa and two generations of offspring obtained after murine spermatogonial stem cell transplantation

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