Tenofovir (TDF) has stronger antiviral effect than adefovir (ADV) against lamivudine (LAM)-resistant hepatitis B virus (HBV)

Hie-Won Hann; Hee Bok Chae; Stephen R. Dunn

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Tenofovir (TDF) has stronger antiviral effect than adefovir (ADV) against lamivudine (LAM)-resistant hepatitis B virus (HBV)

机译：替诺福韦（TDF）对拉米夫定（LAM）耐药的乙型肝炎病毒（HBV）具有比阿德福韦（ADV）更强的抗病毒作用

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摘要

We retrospectively compared the antiviral effect of tenofovir disoproxil fumarate (TDF) with that of adefovir dipivoxil (ADV) for patients with chronic hepatitis B (CHB) who developed resistance to lamivudine (LAM).

机译：我们回顾性地比较了替诺福韦富马酸替诺福韦（TDF）和阿德福韦酯（ADV）对患有拉米夫定（LAM）耐药的慢性乙型肝炎（CHB）患者的抗病毒作用。

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《Hepatology International》 |2008年第2期|244-249|共6页
作者
Hie-Won Hann; Hee Bok Chae; Stephen R. Dunn;
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作者单位

Liver Disease Prevention Center Division of Gastroenterology and Hepatology Department of Medicine Thomas Jefferson University Hospital Philadelphia PA 19107-5587 USA;

Liver Disease Prevention Center Division of Gastroenterology and Hepatology Department of Medicine Thomas Jefferson University Hospital Philadelphia PA 19107-5587 USA;

Cancer Genomics Facility Kimmel Cancer Center Thomas Jefferson University Hospital Philadelphia PA 19107-5587 USA;

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正文语种 eng
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关键词
HBV; Adefovir; Tenofovir; Lamivudine; Viral resistance;

机译：乙肝病毒;阿德福韦;替诺福韦;拉米夫定;病毒耐药;

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专利

1. Tenofovir (TDF) has stronger antiviral effect than adefovir (ADV) against lamivudine (LAM)-resistant hepatitis B virus (HBV) [J] . Hie-Won Hann, Hee Bok Chae, Stephen R. Dunn Hepatology international . 2008,第2期

机译：替诺福韦（TDF）对拉米夫定（LAM）耐药的乙型肝炎病毒（HBV）具有比阿德福韦（ADV）更强的抗病毒作用
2. A randomized trial evaluating the antiviral efficacy of switching from lamivudine plus adefovir to tenofovir disoproxil fumarate monotherapy in lamivudine-resistant chronic hepatitis B patients with undetectable hepatitis B virus DNA [J] . Lee Heon Ju, Kim SangJin, Kweon Young-Oh, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2016,第S1期

机译：一种随机试验，评估从拉米夫定耐慢性乙型肝炎患者中拉米夫鲁德与阿德福韦转换为替莫洛米尔毒性富马特单疗法的抗病毒疗效。
3. Hepatitis B Virus (HBV) Load Response to 2 Antiviral Regimens, Tenofovir/Lamivudine and Lamivudine, in HIV/HBV-Coinfected Pregnant Women in Guangxi, China: The Tenofovir in Pregnancy (TiP) Study [J] . Wang Liming, Wiener Jeffrey, Bulterys Marc, The Journal of Infectious Diseases . 2016,第11期

机译：中国广西HIV / HBV合并感染孕妇对2种抗病毒药物Tenofovir / Lamivudine和Lamivudine的乙型肝炎病毒（HBV）负荷反应：替诺福韦酯（TiP）研究
4. Adefovir dipivoxil for the treatment of chronic hepatitis B infection and in vitro evaluation of hte cross-resistance profiles of lamivudine,famciclovir and adefovir [C] . X Xiong, A Murray, H Yang, Second workshop related to HIV/AIDS in China . 1999

机译：阿德福韦酯对慢性乙型肝炎感染的治疗以及拉米夫定，泛昔洛韦和阿德福韦的交叉耐药性的体外评估
5. Insights into the in vitro replication of the lamivudine-resistant mutant, rtM204I, using the HBV recombinant baculovirus system in HepG2 cells. [D] . Heipertz, Richard Arthur, Jr. 2009

机译：使用HepG2细胞中的HBV重组杆状病毒系统深入了解拉米夫定抗性突变体rtM204I的体外复制。
6. Tenofovir (TDF) has stronger antiviral effect than adefovir (ADV) against lamivudine (LAM)-resistant hepatitis B virus (HBV) [O] . Hie-Won Hann, Hee Bok Chae, Stephen R. Dunn 2008

机译：替诺福韦（TDF）对拉米夫定（LAM）耐药的乙型肝炎病毒（HBV）具有比阿德福韦（ADV）更强的抗病毒作用
7. Tenofovir (TDF) has stronger antiviral effect than adefovir (ADV) against lamivudine (LAM)-resistant hepatitis B virus (HBV) [O] . Hann, Hie-Won, Chae, Hee Bok, Dunn, Stephen R. 2008

机译：替诺福韦（TDF）对拉米夫定（LAM）耐药的乙型肝炎病毒（HBV）具有比阿德福韦（ADV）更强的抗病毒作用

Tenofovir (TDF) has stronger antiviral effect than adefovir (ADV) against lamivudine (LAM)-resistant hepatitis B virus (HBV)

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