β_2 Adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium

摘要

Objective-To define the effects of β_2 adrenergic receptor stimulation on ventricular repolarisa- tion in vivo. Design-Prospective study. Setting-Tertiary referral centre. Patients-85 patients with coronary artery disease and 22 normal controls. Interventions-Intravenous and intracoronary salbutamol (a β_2 adrenergic receptor selective Agonist; 10-30 μg/min and 1-10 μg min), and intravenous isoprenaline (a mixed β_1/β_2 adrenergic Receptor agonist; 1-5 μg/min), infused during fixed atrial pacing.