HIGH-DOSE ALLOPURINOL PROLONGS TIME TO EXERCISE- INDUCED ISCHAEMIA IN CHRONIC STABLE ANGINA

摘要

In patients with chronic stable angina, allopurinol (600 mg/day) improves TET and Tsym and to ischaemia during exercise. These results support the use of allopurinol as a novel anti-ischaemic agent in patients with angina pectoris. They also point towards a potential role for the enzyme xanthine oxidoreductase in the pathophysiology of chest pain in angina pectoris.