Abnormal skeletal muscle bioenergetics in familial hypertrophic cardiomyopathy

摘要

Conclusions-Exercise metabolism was abnormal in both groups of subjects, and the affected contractile protein deter- mined the metabolic changes in muscle at rest and during recovery. In patients with abnormal β myosin heavy chain protein, there was a decrease in oxidative capacity consistent with the reduction in mito- chondria reported in muscle biopsy stud- ies of similar patients. Objective-To determine the skeletal Muscle metabolic manifestations of Familial hypertrophic cardiomyopathy.