Synthesis of Ochratoxin A Derivatives

摘要

Ochratoxin A (OTA) is a toxic fungal secondary metabolite produced by moulds of the genera Penicillium and Aspergillus found in various food and feed samples throughout the world. It is known that this mycotoxin possesses nephrotoxic, teratoge-nic and immunotoxic properties whereas the genotoxicity of the compound is still a matter of controversy. In-Wtro-studies using human kidney cell lines showed that the inhibition of the prote-in biosynthesis is the major toxic principle of the compound. The high efficiency of ochratoxin A has been discussed to be caused by a selective inhibition of the phenylalanyl-tRNA-synthetase [1]. While early publications report a strong affinity of OTA to the enzyme, more recent experiments with purified phenylala-nyl-tRNA-synthetase as well as Computer simulations measu-red only moderate or low binding affinities [2,3].