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Effects of taurine on hepatic lipid metabolism and anti-inflammation in chronic alcohol-fed rats

机译：牛磺酸对慢性酒精喂养大鼠肝脂质代谢和抗炎作用的影响

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摘要

The effects of taurine (Tau) in regulation of lipid metabolism and decreasing inflammation in chronic alcohol-fed rats was investigated. Rats were randomly divided into three groups: (1) isocaloric solution; (2) 3 g alcohol/kg BW/day; (3) 3 g alcohol/kg BW/day + 1 g Tau/kg BW/day for 6 weeks. Liver size and serum/liver lipids of alcohol-fed rats were decreased (p < 0.05) by Tau supplementation, but daily fecal lipid/bile acid outputs were increased (p < 0.05). Regarding de novo lipogenesis, Tau downregulated (p < 0.05) fatty-acid biosynthesis and upregulated (p < 0.05) cholesterol metabolism (CYP7A1) and energy expenditure (PPAR-α). Serum AST and ALT, and hepatic TNF-α levels and MMP-9 activity of alcohol-fed rats were decreased (p < 0.05) by Tau supplementation which may be related to the maintenance of higher (p < 0.05) antioxidant levels (lower thiobarbituric-acid-reactive-substances values and higher trol-ox equivalent antioxidant capacity) in serum and livers. Our study indicates that Tau downregulates lipogenesis, oxidative stress, and inflammation in cnronic alcohol-fed rats.
机译：研究了牛磺酸（Tau）在调节慢性酒精喂养大鼠脂质代谢和减少炎症中的作用。将大鼠随机分为三组：（1）等温溶液； （2）3克酒精/千克体重/天； （3）3克酒精/千克体重/天+ 1克牛磺酸/千克体重/天，持续6周。补充Tau可使酒精喂养大鼠的肝脏大小和血清/肝脂质降低（p <0.05），但每日粪便脂质/胆汁酸产量增加（p <0.05）。关于从头脂肪生成，Tau下调（p <0.05）脂肪酸生物合成，上调（p <0.05）胆固醇代谢（CYP7A1）和能量消耗（PPAR-α）。补充Tau可以降低酒精喂养大鼠的血清AST和ALT以及肝TNF-α水平和MMP-9活性（p <0.05），这可能与维持较高（p <0.05）抗氧化剂水平（降低硫代巴比妥酸）有关。 -血清和肝脏中的酸活性物质值和更高的trol-ox当量抗氧化剂容量）。我们的研究表明，Tau下调了由慢性酒精喂养的大鼠的脂肪生成，氧化应激和炎症。

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  • 来源
    《Food Chemistry》 |2012年第1期|p.24-30|共7页
  • 作者

    Chung-Hsi Chou; Yuan-Yen Chang; Bor-Show Tzang; Chin-Lin Hsu; Yi-Ling Lin; Hui-Wen Lin; Yi-ChenChen;

  • 作者单位

    School of Veterinary Medicine &Zoonoses Research Center, National Taiwan University, Taipei 106, Taiwan;

    Department of Microbiology and Immunology, School of Medicine & Institute of Microbiology and Immunology, Chung Shan Medical University, Takhung 402, Taiwan,Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 402, Taiwan;

    Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 402, Taiwan,Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan;

    School of Nutrition, Chung Shan Medical University, Taichung 402, Taiwan;

    Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 402, Taiwan;

    Department of Veterinary Medicine, National Chung-Hsing University, Taichung 402, Taiwan;

    Department of Animal Science and Technology EtZoonoses Research Center, National Taiwan University, Taipei 106, Taiwan;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    alcohol; liver damage; lipid metabolism; thiobarbituric acid reactive substances; matrix metalloproteinases; trolox equivalent antioxidant capacity;

    机译：醇;肝损害;脂质代谢硫代巴比妥酸反应性物质;基质金属蛋白酶;trolox等效抗氧化能力;

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