The first detection of okadaic acid and its derivatives in Korean bivalves by liquid chromatography-mass spectrometry

摘要

Lipophilic toxin profiles associated with diarrhetic shellfish poisoning in Korean bivalves were investigated by liquid chromatography-mass spectrometry (LC-MS). Okadaic acid (OA), dinophysistoxins (DTX), pectenotoxins (PTX) and yessotoxin (YTX) in bivalves were quantified by LC-MS. Thirty-eight bivalve samples were collected from five different areas on the south coast of Korea during January to June 2006. Dinophysistoxin-1 (DTX1) and OA were found in some samples of both mussel Mytilus edulis and oyster Crassostrea gigas. The levels of DTX1 and OA found in the hepatopancreas of the samples were 0.04–0.23 μg/g and 0.03–0.08 μg/g, respectively. Dinophysistoxin-3 was found in the hepatopancreas of the short-necked clam Ruditapes philippinarum at a concentration of 0.06 μg/g. PTX and YTX were not detected from all of the samples examined. This is the first report of the unambiguous identification of OA and its derivatives, by LC-MS, in Korean bivalves.