Urine proteomic profiling to identify biomarkers of steroid resistance in pediatric nephrotic syndrome

摘要

Long-term prognosis for children with nephrotic syndrome (NS) is directly related to steroidnresponsiveness. There are currently no diagnostic tests that accurately predict steroidnresponsiveness in pediatric NS. The initial prolonged course of daily, high-dose corticosteroidntherapy thus serves both as a diagnostic and therapeutic maneuver. Urine proteomics is emergingnas a potentially rich source of noninvasive biomarkers of drug responsiveness in NS. In this article,nwe discuss some of the initial studies of the urinary proteome in NS as well as ongoing andnfuture challenges, define the normal urinary proteome and address the overwhelming abundancenof urinary albumin and its impact on biomarker discovery.