Optimal dose finding of garenoxacin based on population pharmacokinetics/pharmacodynamics and Monte Carlo simulation

Yusuke Tanigawara; Kenji Nozawa; Hisatsugu Tsuda

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Optimal dose finding of garenoxacin based on population pharmacokinetics/pharmacodynamics and Monte Carlo simulation

机译：基于群体药代动力学/药效学和蒙特卡洛模拟的最佳加雷沙星剂量寻找

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摘要

Garenoxacin, a novel des-F(6)-quinolone, possesses potent antibacterial activity against infectious pathogens in the respiratory tract. Population pharmacokinetic/pharmacodynamic (PK/PD) modeling and Monte Carlo simulations were used to optimize garenoxacin dosage regimens.

机译：加雷沙星是一种新型的des-F（6）-喹诺酮，对呼吸道中的传染性病原体具有强大的抗菌活性。人口药代动力学/药效学（PK / PD）建模和蒙特卡洛模拟用于优化加雷沙星剂量方案。

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来源
《European Journal of Clinical Pharmacology》 |2012年第1期|p.39-53|共15页
作者
Yusuke Tanigawara; Kenji Nozawa; Hisatsugu Tsuda;
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作者单位

Department of Clinical Pharmacokinetics and Pharmacodynamics, School of Medicine, Keio University, Tokyo, 160-8582, Japan;

Biostatics Group, Clinical Planning Department, Toyama Chemical Co., Ltd, Tokyo, Japan;

Research Laboratories, Toyama Chemical Co., Ltd, Toyama, Japan;

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正文语种 eng
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关键词
Garenoxacin; Population pharmacokinetics; Pharmacodynamics; Monte Carlo simulation; Dose finding; Model-based drug development;

机译：Garenoxacin;种群药代动力学;药效学;Monte Carlo模拟;剂量寻找;基于模型的药物开发;

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1. Optimal dose finding of garenoxacin based on population pharmacokinetics/pharmacodynamics and Monte Carlo simulation [J] . TanigawaraY., NozawaK., TsudaH. European journal of clinical pharmacology . 2012,第1期

机译：基于群体药代动力学/药效学和蒙特卡洛模拟的加雷沙星最佳剂量寻找
2. Optimal dosing regimen of biapenem in Chinese patients with lower respiratory tract infections based on population pharmacokinetic/pharmacodynamic modelling and Monte Carlo simulation [J] . Dong Jing, Xiong Wei, Chen Yuancheng, International journal of antimicrobial agents . 2016,第3期

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3. Population pharmacokinetics of fluconazole in critically ill patients receiving continuous venovenous hemodiafiltration: using Monte Carlo simulations to predict doses for specified pharmacodynamic targets. [J] . Patel K, Roberts JA, Lipman J, Antimicrobial agents and chemotherapy. . 2011,第12期

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5. Evaluating Size-Specific Dose Estimate (SSDE) as an Estimate of Organ Doses Derived from Monte Carlo Simulations of CT Exams [D] . Hardy, Anthony James 2019

机译：评估大小特定的剂量估计（SSDE），作为从CT考试的蒙特卡洛模拟得出的器官剂量的估计
6. Optimal dose finding of garenoxacin based on population pharmacokinetics/pharmacodynamics and Monte Carlo simulation [O] . Yusuke Tanigawara, Kenji Nozawa, Hisatsugu Tsuda -1

机译：基于群体药代动力学/药效学和蒙特卡洛模拟的最佳加雷沙星剂量寻找
7. Optimal dose finding of garenoxacin based on population pharmacokinetics/pharmacodynamics and Monte Carlo simulation [O] . Yusuke Tanigawara, Kenji Nozawa, Hisatsugu Tsuda 2011

机译：基于群体药代动力学/药效学和蒙特卡洛模拟的最佳加雷沙星剂量寻找

Optimal dose finding of garenoxacin based on population pharmacokinetics/pharmacodynamics and Monte Carlo simulation

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