Clinical Implication of Serial Leptin Measurement in Subjects with Type 2 Diabetes Mellitus

摘要

Plasma leptin concentration is closely associated with body fat in humans, with energy restriction in- ducing a greater decrease in plasma leptin than in body fat. Since adequate energy restriction is mandatory in diet therapy of diabetes mellitus especially in obese subjects, the present study was undertaken to evaluate the clinical implication of serial leptin measurement in the management of diabetic patients. Fifty- four consecutive subjects with type 2 diabetes, who were subjected to adjusted energy restriction during hospitalization, were enrolled in the study.