APPLICATION OF LEPTIN ANTAGONISTS FOR TREATMENT OF INSULIN RESISTANCE IN DIABETES MELLITUS TYPE II

摘要

FIELD: medicine, endocrinology. SUBSTANCE: invention proposes pharmaceutical composition comprising antagonist of leptin. Invention relates also to method of treatment of diabetes mellitus II type using this composition, murine leptin fragment and method of its preparing. Invention ensures to reduce insulin-resistance by inhibition of leptin effect. EFFECT: improved method of treatment, valuable medicinal properties. 5 cl, 6 tbl