Self-emulsifying system for improving drug dissolution and bioavailability: in vitro/in vivo evaluation

摘要

The present study focuses on enhancement of the dissolution and oral absorption of poorly water-soluble etodolac. A self-emulsifying drug delivery system (SEDDS) composed of oil, surfactant, and co-surfactant for oral administration was formulated. The SEDDS formulations were optimized by evaluating their ability to self-emulsifying when introduced to an aqueous medium under gentle agitation, and by determination of particle size of the resulting emulsion. Optimized formulation of SEDDS was selected for bioavailability assessment in rabbits. Also, the anti-inflammatory effect of SEDDS formulation was determined in rats, compared with powder drug and etodolac suspension in water (50 mg kg−1).