Blood-to-Brain Glucose Transport and Cerebral Glucose Metabolism Are Not Reduced in Poorly Controlled Type 1 Diabetes

摘要

To test the hypothesis that blood-to-brain glucose transport is reduced in poorly controlled type 1 dia- betes, we studied seven patients with a mean (±SD) HbA_1c level of 10.1±1.2/100 and nine nondiabetic subjects During hyperinsulinemic, mildly hypoglycemic (～3.6 Mmol/l～65 mg/dl) glucose clamps. Blood-to-brian glu- Cose transport and cerebral glucose metabolism were Calculated form rat constant derived for blood and Brian time-activity curves-the latter determined by Positron emission tomography (PET)-after intra- Venous injection of [1~-11C]glucose using a model that Includes a fourth rate constant to account for regional Egress of ~11C metabolities.