Antioxidants Diminish Developmental Damage Induced by High Glucose and Cyclooxygenase Inhibitors in Rat Embryos in Vitro

摘要

Previous studies have suggested that the metabolism of arachidonic acid and radical oxygen species (ROS) are altere din diabetes and that these disturbances may induce severe embryonic dysmorphogenesis in diabetic pregnancy. We tested this hypothesis by studying whether an inhibition of the rate-limiting enzyme of prostaglandin biosynthesis, cyclooxygenase (COX), caused developmental disturbances analogous to those seen in embryos exposed to high glucose concentra- tion. Whether antioxidants could prevent such devel- opmental alterations was also investigated.