A Quantitative Trait Locus Influencing BMI Maps to the Region of the β-3 Adrenergic Receptor

摘要

The β-3 adrenergic receptor (ADRB3) has been impli- cated as a regulator of energy expenditure, and a poly- morphism in codon 64 of this gene (Trp64Arg) has been associated in some studies with obesity and insulin resistance. However, many studies have failed to detect an effect of this variant, and the importance of the Trp64Arg variant in human obesity remains controver- Sial. We performed a quantitative linkage analysis of the ADRB3 and obesity, using 12 markers (including the Intragenic Trp64Arg polymorphism) spanning a 57-cM Region of chromosome 8. The study population con- Sisted of 470 individuals from 10 large multigenera- Tional families of Mexican-American ancestry residing In San Antonio, TX. In two-point analysis, logarithm of Odds (LOD) scores >1.0 were observed for six markers Surrounding ADRB3 in a 33-cM region spanned by Markers D8S1477 and D8S1136.