Glucose Entrainment of High-Frequency Plasma Insulin Oscillatios in Control and Type 2 Diabetic Subjects

摘要

Regular high-frequency oscillations of insulin secre- tio are characteristic of normal β-cell function. These oscillations are easily entrainable to an exogenous rhythm by small changes in glucose concentration in vitro. We tested whether high-frequency insulin oscil- lations in vivo would also be entrainable by glucose and whether a lack of entrainment would characterize the diabetic β-cell. We tested 13 control subjects and 11 patients with type 2 diabetes. Subjects underwent ser- ial blood sampling at 1-min intervals for 60-120 min in the basal state or with small (15 mg/kg) boluses of glu- cose injected intravenously at exact 29-min intervals. Time series analysis was carried out using spectral Analysis.