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首页> 外文期刊>Diabetes >Advanced Glycation End Products in Extracellular Matrix Proteins Contribute to the Failure of Sensory Nerve Regeneration in Diabetes
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Advanced Glycation End Products in Extracellular Matrix Proteins Contribute to the Failure of Sensory Nerve Regeneration in Diabetes

机译：细胞外基质蛋白中的高级糖基化终产物促成糖尿病感觉神经再生的失败

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摘要

The goal of this study was to characterize glycation adducts formed in both in vivo extracellular matrix (ECM) proteins of endoneurium from streptozotocin (STZ)-induced diabetic rats and in vitro by glycation of laminin and fibronectin with methylglyoxal and glucose. We also investigated the impact of advanced glycation end product (AGE) residue content of ECM on neurite outgrowth from sensory neurons.
机译：这项研究的目的是表征在链脲佐菌素（STZ）诱导的糖尿病大鼠的神经内膜的体内细胞外基质（ECM）蛋白中形成的糖基化加合物，以及在体外通过层粘连蛋白和纤连蛋白与甲基乙二醛和葡萄糖的糖化来表征糖基化加合物。我们还研究了ECM的高级糖基化终产物（AGE）残留物含量对感觉神经元神经突生长的影响。

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  • 来源
    《Diabetes 》 |2009年第12期| p.2893-2903| 共11页
  • 作者

    Beatriz Duran-Jimenez Darin Dobler Sarah Moffatt Naila Rabbani Charles H Streuli Paul J Thornalley David R Tomlinson Natalie J Gardiner;

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    Beatriz Duran-Jimenez,1 Darin Dobler,2 Sarah Moffatt,1 Naila Rabbani,2 Charles H. Streuli,1 Paul J. Thornalley,2 David R. Tomlinson,1 and Natalie J. Gardiner1From the 1 Faculty of Life Sciences, University of Manchester, Manchester, U.K., and the 2 Clinical Sciences Research institute, Warwick Medicai School, University of Warwick, Coventry, U.K.Corresponding author Natalie J. Gardiner, natalie.gardiner@manchester.ac.ukReceived 5 March 2009 and accepted 15 August 2009. Published ahead of print at http://diabetes.diabetesjournaJs.org on 31 August 2009. DOi: 10.2337/ db09-0320.© 2009 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work Ls not altered. See http://creativeconunons.org/Iicenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "adwrtisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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