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Hypermetabolism, Hyperphagia, and Reduced Adiposity in Tankyrase-Deficient Mice

机译：坦科聚合酶缺乏症小鼠的代谢亢进，吞噬和肥胖减少

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摘要

Tankyrase (TNKS) is a Golgi-associated poly-ADP-ribose polymerase that is implicated in the regulation of GLUT4 trafficking in 3T3-L1 adipocytes. Its chromosomal locus 8p23.1 is linked to monogenic forms of diabetes in certain kindred. We hypothesize that TNKS is involved in energy homeostasis in mammals.
机译：Tankyrase（TNKS）是高尔基体相关的聚ADP-核糖聚合酶，与3T3-L1脂肪细胞中GLUT4转运的调控有关。它的染色体基因座8p23.1与某些种类的糖尿病的单基因形式有关。我们假设TNKS参与哺乳动物的能量稳态。

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  • 来源
    《Diabetes》 |2009年第11期|p.2476-2485|共10页
  • 作者

    Tsung-Yin J Yeh Kristina K Beiswenger Pingping Li Krista E Bolin Ray M Lee Tsu-Shuen Tsao Anne N Murphy Andrea L Hevener Nai-Wen Chi;

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    Tsung-Yin J. Yeh,1 Kristina K. Beiswenger,1 Pingping Li,1 Krista E. Bolin,2 Ray M. Lee,'1 Tsu-Shuen Tsao,2 Anne N. Murphy,1 Andrea L. Hevener/' and Nai-Wen Chi1From the 'Department of Medicine, Endocrine Division. University of California, San Diego, La Jolla. California, the "Department of Biochemistry and Molecular Biophysics. University of Arizona. Tucson, Arizona: 'Lesioni, Inc.. Richmond, Virginia, the 'Department of Pharmacology, University of California, San Diego. Li .lolla, California: and the "'Department of Medicine. University of California, Los Angeles. Los Angeles, California.Corresponding author, Nai-Wen Chi, nwchi@ucsd.edu.Received 22 December 20(18 and accepted 1-1 July 200!). Published ahead of prinl at http://diabetes.diabetesjounials.org on -i August 2(H)!». DOL l0.2337/db08-1781.© 2009 by die American Diabetes Association. Readers may use this article as long as ihe work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creaaveconmions.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicated this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-17 13:45:51

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