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首页> 外文期刊>Diabetes >Genetic Variation in KCNQ1 Associates With Fasting Glucose and [beta]-Cell Function: A Study of 3,734 Subjects Comprising Three Ethnicities Living in Singapore
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Genetic Variation in KCNQ1 Associates With Fasting Glucose and [beta]-Cell Function: A Study of 3,734 Subjects Comprising Three Ethnicities Living in Singapore

机译：与禁食葡萄糖和β-细胞功能相关的KCNQ1的遗传变异：对居住在新加坡的三个族裔的3734名受试者的研究

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摘要

The potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1) has been found through a genome-wide association study to be a strong candidate for conferring susceptibility to type 2 diabetes in East Asian and European populations. Our objective was to describe the association between polymorphisms at the KCNQ1 locus with insulin resistance, beta-cell function, and other type 2 diabetes-related traits in a sample of Chinese, Malays, and Asian Indians living in Singapore.
机译：通过全基因组关联研究发现，钾电压门控通道KQT样亚家族成员1（KCNQ1）是赋予东亚和欧洲人群2型糖尿病易感性的强大候选者。我们的目的是描述生活在新加坡的华裔，马来人和亚洲印第安人的样本中，KCNQ1基因座多态性与胰岛素抵抗，β细胞功能及其他2型糖尿病相关性状之间的关联。

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  • 来源
    《Diabetes》 |2009年第6期|p.1445-1449|共5页
  • 作者

    Jonathan T Tan Siti Nurbaya Daphne Gardner Sandra Ye E Shyong Tai Daniel P K Ng;

  • 作者单位

    Jonathan T. Tan,1 Siti Nurbaya,2 Daphne Gardner,1 Sandra Ye,2 E. Shyong Tai,1 and Daniel P.K. Ng2From the 1 Department of Endocrinology, Singapore General Hospital, Singapore, and the 2 Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore.Corresponding author. Daniel P.K. Ng, cofnpkd@nus.edu.sg.Received 21 August 2008 and accepted 22 February 2009.Published ahead of print at http://diabetes.diabetesjournals.org on 27 February 2009. DOl: 10.2337/db08-1138.© 2009 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See httpy'/crearivecommons.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 入库时间 2022-08-17 13:45:54

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