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Müller Cell-Derived VEGF Is Essential for Diabetes-Induced Retinal Inflammation and Vascular Leakage

机译：Müller细胞衍生的VEGF对于糖尿病诱导的视网膜炎症和血管渗漏至关重要

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摘要

Vascular endothelial growth factor (VEGF-A or VEGF) is a major pathogenic factor and therapeutic target for diabetic retinopathy (DR). Since VEGF has been proposed as a survival factor for retinal neurons, defining the cellular origin of pathogenic VEGF is necessary for the effectiveness and safety of long-term anti-VEGF therapies for DR. To determine the significance of Müller cell-derived VEGF in DR, we disrupted VEGF in Müller cells with an inducible Cre/lox system and examined diabetes-induced retinal inflammation and vascular leakage in these conditional VEGF knockout (KO) mice.
机译：血管内皮生长因子（VEGF-A或VEGF）是糖尿病性视网膜病变（DR）的主要致病因子和治疗靶标。由于已经提出将VEGF作为视网膜神经元的存活因子，因此对于DR的长期抗VEGF疗法的有效性和安全性，定义病原性VEGF的细胞起源是必要的。为了确定DR中Müller细胞来源的VEGF的重要性，我们用可诱导的Cre / lox系统破坏了Müller细胞中的VEGF，并在这些条件性VEGF敲除（KO）小鼠中检查了糖尿病引起的视网膜炎症和血管渗漏。

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  • 来源
    《Diabetes》 |2010年第9期|p.2297-2305|共9页
  • 作者

    Juanjuan Wang Xueliang Xu Michael H Elliott Meili Zhu Yun-Zheng Le;

  • 作者单位

    Juanjuan Wang,1,2,3 Xueliang Xu,1 Michael H. Elliott,4,5 Meili Zhu,2,3 and Yun-Zheng Le 2,3,5,6From the 1Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China, the 2 Department of Medicine Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, the 3 Harold Hamm Oklahoma Diabetes Center, University of Oklahoma, Oklahoma City, Oklahoma, the 4 Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, the 5 Dean A. McGee Eye Institute, Oklahoma City, Oklahoma, and the 6 Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.Corresponding author: Yun-Zheng Le, yun-le@ouhsc.edu.Received 23 September 2009 and accepted 2-1 May 2010. Published ahead of print at http://cliabetes.diabetesjournals.org on 8 June 2010. DOI: 10.2337/db09-1420.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page chatties. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely in indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-17 13:45:43

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