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Kinetics of Contraction-Induced GLUT4 Translocation in Skeletal Muscle Fibers From Living Mice

机译：小鼠骨骼肌纤维收缩诱导的GLUT4易位的动力学。

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摘要

Exercise is an important strategy for the treatment of type 2 diabetes. This is due in part to an increase in glucose transport that occurs in the working skeletal muscles. Glucose transport is regulated by GLUT4 translocation in muscle, but the molecular machinery mediating this process is poorly understood. The purpose of this study was to 1) use a novel imaging system to elucidate the kinetics of contraction-induced GLUT4 translocation in skeletal muscle and 2) determine the function of AMP-activated protein kinase alpha2 (AMPKalpha2) in this process.
机译：运动是治疗2型糖尿病的重要策略。这部分是由于在工作骨骼肌中发生的葡萄糖转运增加。葡萄糖的转运受肌肉中GLUT4易位的调节，但是对介导该过程的分子机制了解甚少。这项研究的目的是：1）使用新型成像系统阐明骨骼肌中收缩诱导的GLUT4易位的动力学，以及2）在此过程中确定AMP激活的蛋白激酶alpha2（AMPKalpha2）的功能。

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  • 来源
    《Diabetes》 |2010年第9期|p.2134-2144|共11页
  • 作者

    Hans P M M Lauritzen Henrik Galbo Taro Toyoda Laurie J Goodyear;

  • 作者单位

    Hans P.M.M. Lauritzen,1 Henrik Galbo,2 Taro Toyoda,1 and Laurie J. Goodyear1From the 1 Research Division, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts: and the 2 Department of Rheumatology and Institute of Inflammation Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.Corresponding author: Laurie J. Goodyear. laurie.goodyear@joslin.harvard.edu.Received 17 February 2010 and accepted 24 June 2010. Published ahead of print at http://diabetes.diabetesjournals.org on 9 July 2010. DOl 10.2337/ db10-0233.© 2010 by the American Diabetes Association. Headers may use this article as long as the work is properly cited, the use is educational and not for profit. and the work is not altered. Sec http://creativecommons.org/licenses/by -nc-nd/3.0/ for detailsThe costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 入库时间 2022-08-17 13:45:42

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