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首页> 外文期刊>Diabetes >Infection With Viruses From Several Families Triggers Autoimmune Diabetes in LEW.1WR1 Rats: Prevention of Diabetes by Maternal Immunization
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Infection With Viruses From Several Families Triggers Autoimmune Diabetes in LEW.1WR1 Rats: Prevention of Diabetes by Maternal Immunization

机译：感染几个家庭的病毒会触发LEW.1WR1大鼠自身免疫性糖尿病：通过母体免疫预防糖尿病

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摘要

The contribution of antecedent viral infection to the development of type 1 diabetes in humans is controversial. Using a newer rat model of the disease, we sought to 1) identify viruses capable of modulating diabetes penetrance, 2) identify conditions that increase or decrease the diabetogenicity of infection, and 3) determine whether maternal immunization would prevent diabetes.
机译：先前的病毒感染对人类1型糖尿病发展的贡献是有争议的。使用该疾病的新大鼠模型，我们寻求1）鉴定能够调节糖尿病渗透性的病毒，2）鉴定增加或降低感染的致糖尿病性的疾病，以及3）确定母体免疫是否可以预防糖尿病。

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  • 来源
    《Diabetes》 |2010年第1期|p.110-118|共9页
  • 作者

    Rebecca S Tirabassi Dennis L Guberski Elizabeth P Blankenhorn Jean H Leif Bruce A Woda Zhijun Liu Donald Winans Dale L Greiner John P Mordes;

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    Rebecca S. Tirabassi,1 Dennis L. Guberski,1 Elizabeth P. Blankenhorn,2 Jean H. Leif,3 Bruce A. Woda,4 Zhijun Liu,5 Donald Winans,1 Dale L. Greiner,3 and John P. Mordes5From 1 BioMedical Research Models, Worcester, Massachusetts, the "Department of Microbiology and Immunology. Center for Immunogenetics and Inflammatory Diseases. Drexel University College of Medicine, Philadelphia, Pennsylvania, the 'Division of Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, the department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, and the "Division of Endocrinology and Metabolism, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.Corresponding author: Dennis L. Guberski, dguberski@biomere.com.Received 20 February 2009 and accepted 15 September 2009. Published ahead of print at http://diabetes.diabetesjournals.org on 30 September 2009. DOI: 10.2337/db09-0255.The contents of dus publication are solely the responsibility of the authors and do not necessarily represent die official views of the National Institutes of Health.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of Otis article were defrayed in part by the payment of page charges. This article must therefore or hereby marked "advertisement" in accordance with IN U.S.C. Settimi 1734 solely tu indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-17 13:45:38

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