Exercise and Thiazolidinedione Therapy Normalize Insulin Action in the Obese Zucker Fatty Rat

摘要

Thiazolidinediones and exercise are both known to iomprove insulin action indepdently. Therefore, we determined whether combined therapy could normalize insulin action in the Zucker fatty (ZF) rat. Rats were fed troglitazone as a 0.2/100 food admixture over a 3-week exercise training period (treadmill running 5 days/week, 20 m/min, 0/100 grade, 60 min/day). Subsequent to drug and/or exercise therapy, animals were chronically can- nulated in the carotid artery (sampling) and jugular vein (infusion. After a 4-day recovery from surgery, animals were exposed to a hyperinsulinemic (40 mU.kg~-1. Min~-1) euglycemic clamp (8.5±0.12 mmol/l; P=0.45 Between groups).