Improved metabolic status and insulin sensitivity in obese fatty (fa/fa) Zucker rats and Zucker Diabetic Fatty(ZDF) rats treated with the thiazolidinedione, MCC-555

摘要

We examined the effect of chronic (21 days) oral treatment with the thiazolidinedione, MCC-555 ((±)-5-[{6-(2-fluorbenzyl)-oxy-2-naphy}methyl]-2,4-tiazolidinedione) on metabolic status and insulin sensitivity in obese (fa/fa) Zucker rats and Zucker Diabetic Fatty (ZDF) rats which display a impaired glucose tolerance(IGT) or overt diabetic symptoms, respectively. MCC-555 treatment to obese Zucker rats(10 and 30 mg kg~-1) and diabetic ZDF rats(10 mg kg~-1) Reduced non-esterified fatty acid concentrations in both rat strains and reduced plasma glucose and Triglyceride concentrations in the obese Zucker rats.