The c-Jun Amino-Terminal Kinase Pathway Is Preferentially Activated by Interleukin-1 and Controls Apoptosis in Differentiating Pancreatic β-Cells

摘要

To characterize the differentiation events that selec- tively target insulin-producing cells to interleukin (IL)- 1 β-induced apoptosis, we studied IL-1β signaling via mitogen-activated protein kinase (MAPK) and stress- activated protein kinase in 2 pancreatic endocrine cell lines. We studied the glucagon-secreting AN-glu cell line and the insulin and the islet amyloid polypeptide- producing β-cell line (AN-ins cells), which is derived by stable transfection of AN-glu cells with the transcript- tion factor pancreatic duodenal homeobox factor-1.