Obesity Indued by a High-Fat Diet Is Associated With Reduced Brain Insulin Transport in Dogs

摘要

Insulin transported form plasma into the central nervous system (CNS) is hypothesized to contribute to the neg- ative feedback regulation of body adiposity. Because CNS insulin uptake is likely mediated by insulin recep- Tors, physiological interventions that impair insulin Action in the periphery might also reduce the efficiency Action in the periphery might also reduce the efficiency Of CNS insulin uptake and predispose to weight gain. We Hypothesized that high-fat feeding, which both reduces Insulin sensitivity in peripheral tissues and favors Weight gain, reduces the efficiency of insulin uptake From plasma into the CNS.