Delayed Insulin Transport Across Endothelium in Insulin-Resistant JCR:LA-cp Rats

摘要

Capillary endothelial cells are thought to limit the transport of insulin across the endothelium, resulting in attenuated insulin action at target sites. Whether endothelial insulin transport is altered in dysglycemic insulin-resistant states is not clear and was therefore investigated in the JCR:LA-cp corpulent male, rat, which exhibits the metabolic syndrome of obesity, insulin resistance, hyperlipidemia, and hyperinsuline- mai.