Anti-Inflammatory Actions of 15-Deoxy-Δ~12,14-Prostaglandin J_2 and Trogliazone Evidence for Heat Shock-Dependent And-Independent Inhibition of Cytokine-Induced Inducible Nitric oxide Synthase Expression

摘要

In this study, the anti-inflammatory actions of the per- oxisome proliferator-activated receptor (PPAR)-γ agonists 15-deoxy-Δ ~12,14-prostaglandin J_2 (15-d-Δ ~12,14-PGJ_2) and troglitazone have been examined. Treat- ment of RAW 264.7 cells and CD-1 mouse peritoneal macrophages with lipopolysaccharide (LPS)+inter- feron-γ(IFN-γ) results in inducible nitric oxide syn- thase (iNOS), inducible cyclooxygenase (COX-2) and interleukin-1 (IL-1) expression, increased production of nitric oxide, and the release of IL-1.