Phenotypic correction of diabetic mice by adenovirus-mediated glucokinase expression

摘要

Hyperglycemia of diabetes is caused in part by pertur- bation of hepatic glucose metabolism. Hepatic glucoki- nase(GK)is an important regulator of glucose storage and disposal in the liver. GK levels are lowered in patients with maturity-onset diabetes of the young and in some diabetic animal models. Here, we explored the adenoviral vector-mediated overexpression of GK in a diet-induced murine model of type 2 diabetes as a treatment for diabetes.